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KMID : 0644120150280010001
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Journal of Oriental Gynecology
2015 Volume.28 No. 1 p.1 ~ p.12
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Effects of Taraxaci Herba on the Sex Hormon Changes and Lipid Metabolism in the Ovariectomized Rats
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Kim Ji-Eun
Yang Seung-Jeong
Cho Seong-Hee
Park Kyung-Mi
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Abstract
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Objectives: Taraxaci Herba (TH) have been used in oriental medicine for many centuries as a heat-clearing, detoxifying and stimulating milk secretion drug. Therefore, the purpose of this study was to investigate the effects of TH on the sex hormone changes and lipid metabolism in the experimental model.
Methods: The experimental model of menopause was induced by bilateral ovariectomy in rats. We used TH extract with freeze-dried and 200±20 g female Sprague-dawley rats for this Study. The level of serum total cholesterol, serum triglyceride, serum HDL-cholesterol, serum total estrogen, serum progesterone, serum follicle stimulating hormone (FSH), and body weight were measured.
Results: The results of this study were obtained as follows;
1. Sample A and Sample B significantly decreased body weight and level of serum total cholesterol, and significantly increased level of serum total estrogen as compared with control group.
2. Sample A decreased level of serum triglyceride, and was increased level of HDLcholesterol,
serum progesterone, serum FSH as compared with control group.
3. Sample B significantly increased level of HDL-cholesterol, serum FSH as compared with control group.
4. Sample B decreased level of serum triglyceride, and was increased level of serum progesterone as compared with control group.
Conclusions: These results suggest that TH could be applied effectively on the treatment of menopausal syndrome.
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KEYWORD
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Menopausal Syndrome, Taraxaci Herba, Sex Hormon Changes, Lipid Metabolism
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